Sinn Sisamuth (Khmer: ស៊ីន ស៊ីសាមុត [sɨn siːsaːmut]; 23 August 1932 – 18 June 1976) was a famous and highly prolific Cambodian singer-songwriter in the 1950s to the 1970s.

Widely considered the "King of Khmer music", Sisamuth, along with Ros Serey Sothea, Pan Ron, and other artists, was part of a thriving pop music scene in Phnom Penh that blended elements of Khmer traditional music with the sounds of rhythm and blues and rock and roll to make a Westernized sound akin to psychedelic or garage rock. Sisamuth is believed to have been killed under the Khmer Rouge regime.